PT - JOURNAL ARTICLE AU - Eduardo R. Lazarowski AU - T. Kendall Harden TI - UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiological Consequences of P2Y<sub>14</sub> Receptor Activation AID - 10.1124/mol.115.098756 DP - 2015 Jan 01 TA - Molecular Pharmacology PG - mol.115.098756 4099 - http://molpharm.aspetjournals.org/content/early/2015/04/02/mol.115.098756.short 4100 - http://molpharm.aspetjournals.org/content/early/2015/04/02/mol.115.098756.full AB - UDP-sugars, which are indispensable for protein glycosylation reactions in cellular secretory pathways, also act as important extracellular signaling molecules. We discuss here the broadly expressed P2Y14 receptor (P2Y14R), a G protein-coupled receptor (GPCR) targeted by UDP-sugars, and the increasingly diverse set of physiological responses discovered recently functioning downstream of this receptor in many epithelia as well as in immune, inflammatory, and other cells.