PT - JOURNAL ARTICLE AU - Kelly Monk AU - Jorg Hamann AU - Tobias Langenhan AU - Saskia Nijmeijer AU - Torsten Schoneberg AU - Ines Liebscher TI - Adhesion GPCRs: From In Vitro Pharmacology to In Vivo Mechanisms AID - 10.1124/mol.115.098749 DP - 2015 Jan 01 TA - Molecular Pharmacology PG - mol.115.098749 4099 - http://molpharm.aspetjournals.org/content/early/2015/05/08/mol.115.098749.short 4100 - http://molpharm.aspetjournals.org/content/early/2015/05/08/mol.115.098749.full AB - The adhesion family of G protein-coupled receptors (aGPCRs) comprises 33 human members. aGPCRs are characterized by their enormous size and complex modular structures. While the physiologic importance of many aGPCRs has been clearly demonstrated in recent years, the underlying molecular functions have only recently begun to be elucidated. In this minireview, we present an overview of our current knowledge on aGPCR activation and signal transduction with a focus on the latest findings regarding the interplay between ligand binding, mechanical force, and the tethered agonistic Stachel sequence, as well as implications on translational approaches that may derive from understanding aGPCR pharmacology.