PT  - JOURNAL ARTICLE
AU  - Paula G Slater
AU  - Hector E Yarur
AU  - Katia Gysling
TI  - Corticotropin-releasing factor receptors and their interacting proteins: functional consequences
AID  - 10.1124/mol.116.104927
DP  - 2016 Jan 01
TA  - Molecular Pharmacology
PG  - mol.116.104927
4099  - http://molpharm.aspetjournals.org/content/early/2016/09/09/mol.116.104927.short
4100  - http://molpharm.aspetjournals.org/content/early/2016/09/09/mol.116.104927.full
AB  - The corticotropin-releasing factor (CRF) system is involved in stress and addiction as well as in anxiety disorders such as depression. CRF acts through type-1 and type-2 CRF receptors. Both types of receptors are G-protein coupled receptors (GPCRs). The purpose of this minireview is to highlight recent advances on the interactions of CRF receptors with other GPCRs and non-GPCR proteins, and their associated functional consequences. The better understanding of these interactions may generate new pharmacological alternatives for the treatment of addiction and stress-related disorders.