PT  - JOURNAL ARTICLE
AU  - Isabella G. Olmo
AU  - Talita H. Ferreira-Vieira
AU  - Fabiola M. Ribeiro
TI  - Dissecting the Signaling Pathways Involved in the Crosstalk between Metabotropic Glutamate 5 and Cannabinoid Type 1 Receptors
AID  - 10.1124/mol.116.104372
DP  - 2016 Nov 01
TA  - Molecular Pharmacology
PG  - 609--619
VI  - 90
IP  - 5
4099  - http://molpharm.aspetjournals.org/content/90/5/609.short
4100  - http://molpharm.aspetjournals.org/content/90/5/609.full
SO  - Mol Pharmacol2016 Nov 01; 90
AB  - The metabotropic glutamate 5 receptor and the cannabinoid type 1 receptor are G protein–coupled receptors that are widely expressed in the central nervous system. Metabotropic glutamate 5 receptors, present at the postsynaptic site, are coupled to Gαq/11 proteins and display an excitatory response upon activation, whereas the cannabinoid type 1 receptor, mainly present at presynaptic terminals, is coupled to the Gi/o protein and triggers an inhibitory response. Recent studies suggest that the glutamatergic and endocannabinoid systems exhibit a functional interaction to modulate several neural processes. In this review, we discuss possible mechanisms involved in this crosstalk and its relationship with physiologic and pathologic conditions, including nociception, addiction, and fragile X syndrome.