RT Journal Article SR Electronic T1 Title:Dynamin Functions and Ligands: Classical Mechanism Behind JF Molecular Pharmacology JO Mol Pharmacol FD American Society for Pharmacology and Experimental Therapeutics SP mol.116.105064 DO 10.1124/mol.116.105064 A1 Mahaveer Singh II A1 Hemant Jadhav A1 Mahaveer Singh YR 2016 UL http://molpharm.aspetjournals.org/content/early/2016/11/22/mol.116.105064.abstract AB Dynamin is a GTPase, which plays a vital role in clathrin dependent endocytosis and other vesicular trafficking processes. Dynamin acts as scissor with debatable mechanism for newly formed vesicles originating from plasma membrane. Dynamin related proteins are important components in scission of various organelles such as clathrin coated vesicles, phagosomes and mitochondria, etc. helping in organelle division, viral resistance and mitochondrial fusion/division. Dysfunction and mutations in dynamin have been implicated in various disorders, where endocytic trafficking is involved, such as Alzheimer's, Parkinson's, Huntington's, Charcot-Marie Tooth disease, Heart failure, Schizophrenia, Epilepsy, Cancer, Optic atrophy, Down syndrome, Osteoporosis etc. This review is an attempt to illustrate the dynamin related mechanism involved in these disorders and to help medicinal chemist in designing novel agents as dynamin ligands.