PT - JOURNAL ARTICLE AU - Singh, Mahaveer AU - Jadhav, Hemant R. AU - Bhatt, Tanya TI - Dynamin Functions and Ligands: Classical Mechanisms Behind AID - 10.1124/mol.116.105064 DP - 2017 Feb 01 TA - Molecular Pharmacology PG - 123--134 VI - 91 IP - 2 4099 - http://molpharm.aspetjournals.org/content/91/2/123.short 4100 - http://molpharm.aspetjournals.org/content/91/2/123.full SO - Mol Pharmacol2017 Feb 01; 91 AB - Dynamin is a GTPase that plays a vital role in clathrin-dependent endocytosis and other vesicular trafficking processes by acting as a pair of molecular scissors for newly formed vesicles originating from the plasma membrane. Dynamins and related proteins are important components for the cleavage of clathrin-coated vesicles, phagosomes, and mitochondria. These proteins help in organelle division, viral resistance, and mitochondrial fusion/fission. Dysfunction and mutations in dynamin have been implicated in the pathophysiology of various disorders, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Charcot-Marie-Tooth disease, heart failure, schizophrenia, epilepsy, cancer, dominant optic atrophy, osteoporosis, and Down’s syndrome. This review is an attempt to illustrate the dynamin-related mechanisms involved in the above-mentioned disorders and to help medicinal chemists to design novel dynamin ligands, which could be useful in the treatment of dynamin-related disorders.