TY - JOUR T1 - Dynamin Functions and Ligands: Classical Mechanisms Behind JF - Molecular Pharmacology JO - Mol Pharmacol SP - 123 LP - 134 DO - 10.1124/mol.116.105064 VL - 91 IS - 2 AU - Mahaveer Singh AU - Hemant R. Jadhav AU - Tanya Bhatt Y1 - 2017/02/01 UR - http://molpharm.aspetjournals.org/content/91/2/123.abstract N2 - Dynamin is a GTPase that plays a vital role in clathrin-dependent endocytosis and other vesicular trafficking processes by acting as a pair of molecular scissors for newly formed vesicles originating from the plasma membrane. Dynamins and related proteins are important components for the cleavage of clathrin-coated vesicles, phagosomes, and mitochondria. These proteins help in organelle division, viral resistance, and mitochondrial fusion/fission. Dysfunction and mutations in dynamin have been implicated in the pathophysiology of various disorders, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Charcot-Marie-Tooth disease, heart failure, schizophrenia, epilepsy, cancer, dominant optic atrophy, osteoporosis, and Down’s syndrome. This review is an attempt to illustrate the dynamin-related mechanisms involved in the above-mentioned disorders and to help medicinal chemists to design novel dynamin ligands, which could be useful in the treatment of dynamin-related disorders. ER -