PT  - JOURNAL ARTICLE
AU  - Gongxin Wang
AU  - Kewei Wang
TI  - The Ca2+-permeable cation TRPV3 channel: an emerging pivotal target for itch and skin diseases
AID  - 10.1124/mol.116.107946
DP  - 2017 Jan 01
TA  - Molecular Pharmacology
PG  - mol.116.107946
4099  - http://molpharm.aspetjournals.org/content/early/2017/04/04/mol.116.107946.short
4100  - http://molpharm.aspetjournals.org/content/early/2017/04/04/mol.116.107946.full
AB  - Temperature-sensitive transient receptor potential (thermo-TRP) channels such as TRPA1 and TRPV1 have been indicated as downstream ion channel targets in transduction of itch. As a member of thermos-TRPs, Ca2+-permeable nonselective cation TRPV3 channels are expressed abundantly in the skin keratinocytes. Recent identification of gain-of-function mutations of human TRPV3 from patients with Olmsted Syndrome characterized by severe itching and palmoplantar and periorificial keratoderma unveils its crucial role in chronic itch and skin diseases. In this review, we will focus on recent progress made in the understanding of TRPV3 that emerges as an attractive target for developing effective anti-pruritic therapy for chronic itch or skin related diseases.