TY - JOUR T1 - The Emerging Role of Cables1 in Cancer and Other Diseases JF - Molecular Pharmacology JO - Mol Pharmacol SP - 240 LP - 245 DO - 10.1124/mol.116.107730 VL - 92 IS - 3 AU - Jia-Rong Huang AU - Guang-Mou Tan AU - Yong Li AU - Zhi Shi Y1 - 2017/09/01 UR - http://molpharm.aspetjournals.org/content/92/3/240.abstract N2 - Cdk5 and Abl enzyme substrate 1 (Cables1) is an adaptor protein that links cyclin-dependent kinase (Cdks) with nonreceptor tyrosine kinases and regulates the activity of Cdks by enhancing their Y15 phosphorylation. Emerging evidence also shows that Cables1 can interact with, for example, p53 family proteins, 14-3-3, and β-catenin, suggesting that Cables1 may be a signaling hub for the regulation of cell growth. Abnormal expression of Cables1 has been observed in multiple types of cancers and other diseases. In this review, we summarize the characteristics of Cables1 and highlight the molecular mechanisms through which Cables1 regulates the development of cancer and other diseases. Finally, we discuss future challenges in demonstrating the role and potential application of Cables1 in cancer and other diseases. ER -