RT Journal Article
SR Electronic
T1 The Emerging Role of Cables1 in Cancer and Other Diseases
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 240
OP 245
DO 10.1124/mol.116.107730
VO 92
IS 3
A1 Jia-Rong Huang
A1 Guang-Mou Tan
A1 Yong Li
A1 Zhi Shi
YR 2017
UL http://molpharm.aspetjournals.org/content/92/3/240.abstract
AB Cdk5 and Abl enzyme substrate 1 (Cables1) is an adaptor protein that links cyclin-dependent kinase (Cdks) with nonreceptor tyrosine kinases and regulates the activity of Cdks by enhancing their Y15 phosphorylation. Emerging evidence also shows that Cables1 can interact with, for example, p53 family proteins, 14-3-3, and β-catenin, suggesting that Cables1 may be a signaling hub for the regulation of cell growth. Abnormal expression of Cables1 has been observed in multiple types of cancers and other diseases. In this review, we summarize the characteristics of Cables1 and highlight the molecular mechanisms through which Cables1 regulates the development of cancer and other diseases. Finally, we discuss future challenges in demonstrating the role and potential application of Cables1 in cancer and other diseases.