RT Journal Article SR Electronic T1 Caveolins as regulators of stress adaptation JF Molecular Pharmacology JO Mol Pharmacol FD American Society for Pharmacology and Experimental Therapeutics SP mol.117.111237 DO 10.1124/mol.117.111237 A1 Jan M Schilling A1 Brian P Head A1 Hemal H Patel YR 2018 UL http://molpharm.aspetjournals.org/content/early/2018/01/22/mol.117.111237.abstract AB Cavoelins have emerged over the past few decades as key regulators of cell physiology. They are ubiquitously expressed and regulate a number of processes that ultimately impact efficiency of cellular processes. Though not critical to life, they are central to stress adaptation in a number of organs. The following review will focus specifically on the role of caveolin in stress adaptation in the heart, brain, and eye, three organs that are susceptible to acute and chronic stress as well as show declining function with age. In addition, we consider some novel molecular mechanisms that may account for this stress adaptation but also offer potential to drive the future of caveolin research.