RT Journal Article
SR Electronic
T1 G-Protein Coupled Receptor Signaling and Mammalian Target of Rapamycin Complex 1 Regulation
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 181
OP 190
DO 10.1124/molpharm.121.000302
VO 101
IS 4
A1 Melick, Chase H.
A1 Lama-Sherpa, Tshering D.
A1 Curukovic, Adna
A1 Jewell, Jenna L.
YR 2022
UL http://molpharm.aspetjournals.org/content/101/4/181.abstract
AB The mammalian target of rapamycin (mTOR) senses upstream stimuli to regulate numerous cellular functions such as metabolism, growth, and autophagy. Increased activation of mTOR complex 1 (mTORC1) is typically observed in human disease and continues to be an important therapeutic target. Understanding the upstream regulators of mTORC1 will provide a crucial link in targeting hyperactivated mTORC1 in human disease. In this mini-review, we will discuss the regulation of mTORC1 by upstream stimuli, with a specific focus on G-protein coupled receptor signaling to mTORC1.SIGNIFICANCE STATEMENT mTORC1 is a master regulator of many cellular processes and is often hyperactivated in human disease. Therefore, understanding the molecular underpinnings of G-protein coupled receptor signaling to mTORC1 will undoubtedly be beneficial for human disease.