TABLE 2

Bilobalide inhibition parameters at wild-type and mutant 5-HT₃ receptors

Values are presented as mean ± S.E.M.

Receptor	pIC₅₀	IC₅₀	Hill Slope	n
		μM
5-HT₃A	3.33 ± 0.03	468	1.48 ± 0.16	6
D20′E	3.21 ± 0.04	600	1.25 ± 0.12	4
I16′V	3.12 ± 0.04	200	1.43 ± 0.15	5
S12′A	N.I.^*	N.I.	N.I.	3
L9′V	2.79 ± 0.06^*	1600	0.84 ± 0.09	8
L7′T	4.11 ± 0.09^*	78	0.96 ± 0.09	5
T6′S	N.I.^*	N.I.	N.I.	3
S2′A	4.94 ± 0.04^*	11	0.86 ± 0.04	3
E−1′D	3.20 ± 0.12	630	0.67	4
N−4′Q	3.33 ± 0.10	470	1.09 ± 0.20	5
5-HT₃AB^{^a}	2.51 ± 0.15^*	3100	0.68 ± 0.13	4

N.I., no inhibition at 1 mM.
↵a Values taken from Thompson et al. (2011) were recorded at the same time as the current results and can be directly compared.
↵* P < 0.05, significantly different from wild type (ANOVA with Dunnett's post test).