Receptor | Configuration | Maximal Response | EC50 | nH | No. of Cells | Range of Currents at Maximal GABA |
---|---|---|---|---|---|---|
μM | nA | |||||
αβγ | GS/GS | 1.0 ± 0.03 | 4.6 ± 0.4 | 1.4 ± 0.1 | 7 | 675–1780 |
βαγ-βα | GS/GS | 1.0 ± 0.03 | 33 ± 2 | 2.0 ± 0.3 | 5 | 4364–6075 |
βαγ-β*α | GS/–S | 1.0 ± 0.02 | 95 ± 6 | 1.4 ± 0.1 | 6 | 827–2443 |
βαγ-βα* | GS/G– | 1.0 ± 0.01 | 76 ± 3 | 1.9 ± 0.1 | 5 | 1831–5133 |
βαγ-β*α* | GS/– – | 1.0 ± 0.02 | 79 ± 4 | 1.6 ± 0.1 | 5 | 1171–4403 |
βα*γ-βα | G–/GS | 1.0 ± 0.02 | 53 ± 4 | 1.3 ± 0.1 | 5 | 3370–4592 |
βα*γ-β*α | G–/–S | 1.1 ± 0.1 | 94 ± 23 | 1.0 ± 0.2 | 4 | 129–211 |
βα*γ-βα* | G–/G– | 1.1 ± 0.03 | 156 ± 12 | 1.4 ± 0.1 | 5 | 487–1212 |
βα*γ-β*α* | G–/– – | 1.1 ± 0.01 | 126 ± 5 | 1.2 ± 0.05 | 6 | 92–263 |
β*αγ-βα | –S/GS | 1.0 ± 0.02 | 32 ± 2 | 1.1 ± 0.1 | 4 | 277–2823 |
β*αγ-β*α | –S/–S | N.D. | N.D. | N.D. | 5 | <5 |
β*αγ-βα* | –S/G– | 1.1 ± 0.02 | 140 ± 11 | 1.2 ± 0.1 | 7 | 35–142 |
β*αγ-β*α* | –S/– – | N.D. | N.D. | N.D. | 5 | <5 |
β*α*γ-βα | – –/GS | 1.1 ± 0.1 | 24 ± 6 | 1.0 ± 0.2 | 5 | 460–3851 |
β*α*γ-β*α | – –/–S | N.D. | N.D. | N.D. | 6 | <10 |
β*α*γ-βα* | – –/G– | 1.2 ± 0.02 | 187 ± 13 | 1.1 ± 0.1 | 5 | 50–148 |
β*α*γ-β*α* | – –/– – | N.D. | N.D. | N.D. | 4 | <10 |
β*, β(Y205S); α*, α(Q241L); G, intact GABA site; S, intact steroid site; N.D., not determined.