TABLE 2

EC550 values for the four different trypanosomes strains used in this study

s427WTtbat1(−/−)B48ABR
EC50nEC50nRFEC50nRFEC50nRF
nMnMnMnM
Pentamidine6.8 ± 1.11215 ± 6112.2570 ± 200683340 ± 97550
Diminazene629 ± 132125780 ± 1560129.22670 ± 51044.214,600 ± 3900523
DB75212 ± 60121670 ± 460107.9360 ± 11051.74560 ± 1560522
Cymelarsan4.1 ± 0.41213 ± 2123.262 ± 1561527 ± 466.6
PAO0.69 ± 0.1380.76 ± 0.0981.10.54 ± 0.1440.80.82 ± 0.1441.2
  • RF, resistance factor relative to wild-type (s427WT).