TABLE 1

FLB-12 concentrations in mouse and human tumor xenograft tissues

Six- to eight-week-old C57BL/6 female and SCID/NOD mice xenografted with LS174T cells (group average flank tumor volume ∼0.45 mm³) were injected with rifampicin (50 mg · kg⁻¹ · day⁻¹ i.p.) and/or orally gavaged FLB-12 (300 mg · kg⁻¹ · day⁻¹) for 4 days. All tissues were harvested on day 4 for assessment of FLB-12 concentrations, as described under Materials and Methods.