Table 1

IC50 values of AMD3100 for HIV-1 replication in the different U87.CD4.CXCR4 transfectants

CXCR4 MutantIC501-a
NL4.3 strainIIIB strainHE strain
ng/ml
CXCR4[WT]131012
CXCR4[D171N]2944379
CXCR4[D262N]86>200>1000
CXCR4[D171N,D262N]N.A.N.A.>1000
CXCR4[H281A]1.21.81.6
  • 1-a  50% inhibitory concentration of AMD3100 for p24 antigen production, as measured by ELISA in the culture supernatant at day 5 after infection.

  • NA, not applicable because of lack of virus replication.