IC50 | ||
---|---|---|
Ap5A response | ATP response | |
Ip3I | 4.90 ± 0.10 μm | 100.08 ± 5.72 μm |
Ip4I | 8.33 ± 0.22 μm | 29.51 ± 1.40 μm |
Ip5I | 4.23 ± 0.12 nm | 27.75 ± 1.65 μm |
Ap5A and ATP were assayed at a final concentration of 100 μm in the presence of graded concentrations of IpnIs to elaborate dose-response curves. IC50 values represent the concentration of the antagonist producing an inhibition of 50% of the maximal effect induced by the agonists. Values are mean ± standard error.