Table 1

Agonist efficacy and effect of G_αq on agonist potency

Agonist	EC₅₀ (% response)		EC50/EC₅₀(+G)	EC₅₀ (% response)		EC₅₀/EC₅₀(+G)	EC₅₀ (% response)		EC₅₀/EC₅₀ (+G)
Agonist	m1	m1 + G_Q	EC50/EC₅₀(+G)	m3	m3 + G_Q	EC₅₀/EC₅₀(+G)	m5	m5 + G_Q	EC₅₀/EC₅₀ (+G)
	nm		nm		nm
Carbachol	1506 ± 166	87 ± 15	17	693 ± 36	20 ± 4	34	249 ± 21	11 ± 2	22
	(100%)	(100%)		(100%)	(100%)		(100%)	(100%)
Pilocarpine	4718 ± 311	264 ± 31	18	2796 ± 474	156 ± 72	18	2476 ± 135	192 ± 47	13
	(91 ± 12%)	(75 ± 9%)		(64 ± 9%)	(113 ± 4%)		(96 ± 15%)	(103 ± 18%)
Arecoline	514 ± 85	64 ± 28	8	593 ± 90	64 ± 14	9	261 ± 41	18 ± 11	14
	(84 ± 6%)	(86 ± 1%)		(70 ± 3%)	(126 ± 0)		(79 ± 12%)	(94 ± 9%)
McN-A-343	1862 ± 46	273 ± 11	7	4440 ± 81	1090 ± 75	4	1729 ± 49	341 ± 17	5
	(62 ± 36%)	(93 ± 17%)		(38 ± 6%)	(105 ± 26%)		(56 ± 19%)	(98 ± 11%)
O-ethyl-THAO	126 ± 3	40 ± 3	3	193 ± 7	46 ± 2	4	346 ± 1	71 ± 1	5
	(46 ± 17%)	(78 ± 11%)		(23 ± 9%)	(101 ± 38%)		(80 ± 30%)	(93 ± 33%)