Kinetic parameters of oxidation
| Cu/drug ratio | t½ | t | |
|---|---|---|---|
| min | |||
| pH 9.4 | |||
| mAMSA | 0.1 | ||
| SN 16713 | 0.1 | 95 | 300 |
| NetAmsa | 0.1 | 45 | 180 |
| mAMSA | 1 | 135 | 345 |
| SN 16713 | 1 | 37 | 129 |
| NetAmsa | 1 | 6 | 39 |
| mAMSA | 3 | 60 | 165 |
| SN 16713 | 3 | 35 | 100 |
| NetAmsa | 3 | 4 | 25 |
| In the presence of DNA | |||
| mAMSA | 3 | 6.5 | 44 |
| SN 16713 | 3 | 6 | 108 |
| NetAmsa | 3 | 10 | 60 |
| pH 7.0 | |||
| mAMSA | 3 | >1200 | |
| SN 16713 | 3 | 840 | >1200 |
| NetAmsa | 3 | 390 | >1200 |
t½ and t correspond to the time necessary for half and complete oxidation of the ligand, respectively.