Inhibition of HIV-1 integrase by 5′-phosphorylated deoxydinucleotides
| 5′ | 3′ | |||
|---|---|---|---|---|
| A | C | G | T | |
| A | >100 | 6 ± 2 | 15 ± 7 | 7 ± 2 |
| 100 ± 30 | 3 ± 1 | 9 ± 4 | 7 ± 3 | |
| C | 105 ± 20 | 15 ± 0.5 | 71 ± 11 | 8 ± 0.5 |
| 13 ± 5 | 12 ± 5 | 12.4 ± 1.7 | 6 ± 1 | |
| G | >100 | >100 | 54 ± 34 | 22 ± 1 |
| 100 ± 40 | 100 ± 40 | 11.5 ± 3.5 | 7.5 ± 0.5 | |
| T | 85 ± 21 | 35 ± 17 | 65 ± 35 | 73 ± 27 |
| 18 ± 10 | 37 ± 9 | 31 ± 4 | 53 ± 4 | |
For each dinucleotide combination, the first line represents the IC50 for 3′-processing and the lower line the IC50 for strand transfer (in micromolar).