Structure and functional activity relationships of sCT analogues in the constitutively active C1b CTR system
| sCT analogue | Structure | Activity |
|---|---|---|
| sCT | sCT-(1-32) | Agonist |
| SDZ-220-235 | Ac-[Ala7,Aib17]sCT-(2-32) | Agonist |
| SDZ-218-686 | Ala7-sCT-(3-32) | Agonist |
| SDZ-216-710 | Isocaproyl-[Ala7,Aib10,17,Lys(For)11,18,Lys(fructosyl)24]sCT-(5-32) | Partial agonist/antagonist |
| SDZ-212-769 | [Ala7]sCT-(7-32) | Inverse agonist |
| sCT-(8-32) | sCT-(8-32) | Inverse agonist |
| SDZ-219-379 | Ac-[Aib10,17,Lys(For)11,18,Lys(Ip)24]sCT-(8-32) | Inverse agonist |
| AC512 | Bolton-Hunter-[Arg18,Asn30,Tyr32]sCT-(8-32) | Inverse agonist |