Modulator | Obidoxime |
---|---|
pKb | |
Gallamine | 4.70 ± 0.06 |
W84 | 4.61 ± 0.05 |
Alcuronium | 4.30 ± 0.141-b |
WDuo3 | 4.16 ± 0.07 |
Duo3 | 3.00 ± 0.081-d |
The concentrations of obidoxime are given at which the curves for the allosteric action of the respective modulators are shifted to the right by a factor of 2 (i.e., pKb values for interactions compatible with a competitive model, pA 2 values for the interplay with Duo3 that was not compatible with a competitive mechanism; pA 2= pKb /n; see eq. 2 in Data Analysis).2 Values are mean ± standard error, derived from five experiments. EC0.5 values are derived according to Lew and Angus (16). Values were compared using an unpaired two-sample t test.