Results of cytotoxicity assays for 18 compounds selected from the National Cancer Institute Drug Screen Repository
| SW620 IC50 | SW620 Ad300 | DMF1-b | ||
|---|---|---|---|---|
| IC50 | IC50 + CsA | |||
| μg/ml | μg/ml | μg/ml | ||
| NSC number (class)1-a | ||||
| 38270 (S) | 0.002 | 30 | 0.0037 | 8000 |
| 328426 (S) | 0.000001 | 3 | 0.0025 | 1200 |
| 339281 (S) | 1.3 | 200 | 3 | 66.6 |
| 359449 (S) | 0.7 | 150 | 0.100 | 1500 |
| 630176 (S) | 0.002 | 1.5 | 0.00015 | 10000 |
| 633043 (S) | 1.5 | 60 | 0.500 | 120 |
| 640085 (S) | 0.2 | 60 | 0.60 | 100 |
| 666490 (S) | 0.2 | 150 | 0.100 | 1500 |
| 68075 (A) | 8.5 | 10 | 10 | 1 |
| 665333 (A) | 5.5 | 10 | 10 | 1 |
| 667739 (A) | 2.8 | 4 | 10 | 0.4 |
| 676590 (A) | 26 | 20 | 10 | 2 |
| 676591 (A) | 20 | 5 | 5 | 1 |
| 676597 (A) | 2.4 | 1 | 2 | 0.5 |
| 676599 (A) | 33 | 70 | 41 | 1.7 |
| 676600 (A) | N.D. | 10 | 25 | 0.4 |
| 676605 (O) | 80 | 30 | 5 | 6 |
| 668360 (O) | 1.5 | 1 | 0.071 | 14 |
| Vinblastine | 0.04 | 0.00011 | 351 | |
| Doxorubicin | 1.36 | 0.0056 | 241 | |
| Paclitaxel | 0.220 | 0.0022 | 100 | |
| Colchicine | 0.100 | 0.006 | 16.6 | |
| CsA1-c | 7 | 23 | 3.3 | |
| PSC 8331-c | 7 | 21 | 3 | |
| Verapamil1-c | 60 | 90 | 1.5 | |
↵1-a Classification determined by assays in Tables 1 and 2: S, substrate; A, antagonist; and O, compounds in the overlap group.
↵1-b [DMF = IC50/(IC50 + CsA)] in SW620 cells.
↵1-c Cytotoxicity for CsA, verapamil, and PSC 833 has been tested, and the DMF determined through comparison of IC50 value of SW620 Ad300 cells with that of the parental SW620 cells.
N.D., not determined.