Substrate | Captopril | Lisinopril | Fosinoprilat |
---|---|---|---|
nm | |||
Hip-Lys-Pro | 4.12 ± 0.37 | 3.90 ± 0.75 | 4.62 ± 0.53 |
Hip-Ala-Pro | 1.08 ± 0.74 | 1.73 ± 0.22 | 0.74 ± 0.34 |
Hip-His-Leu | 3.42 ± 0.33 | 0.39 ± 0.07 | 0.29 ± 0.11 |
AcSDKP | 0.24 ± 0.01 | 0.24 ± 0.15 | 0.06 ± 0.05 |
Ang I | 3.98 ± 1.70 | 0.36 ± 0.13 | 0.37 ± 0.24 |
Values are mean ± standard error from two or three independent determinations with ENZFITTER software for five inhibitor concentrations in the presence of optimal Cl−concentrations for each substrate as described in Experimental Procedures.