Table 1

Determination of EC50 values of chlordiazepoxide and phenobarbital in wild-type and picrotoxinin-insensitive mutants

Ionophore compositionEC50
ChlordiazepoxidePhenobarbital
μm
α1β2γ2 (wt)3.1ND1-a
α1Mβ2γ211.41-b ND
α1β2Mγ21.0ND
α1β2γ2M 1.2ND

  • ↵1-a ND, not determined.

  • ↵1-b Different (p < 0.05) from wild-type mutants by ANOVA followed by Dunnett’s test.