Table 3

Mutations in the gp120 of DSr NL4-3

Amino acid position (region)3-aNL4-3 wild-type strainNL4-3 DSr strain
CodonAmino acidCodonAmino acid
113  (V1)AGTSAATN
134  (V2)AGCSAACN
269  (V3)AAAKGAAE
278  (V3)CAGQCATH
293  (V3)AATNGATD
323  (C3)AATNAGTS
Δ364-368  (V4)TTT AAT AGT ACT TGGFNSTWDeletion
387  (CD4BD)3-b AGARACAI

  • ↵3-a Numbering of amino acid and domain classification according to the published secondary structure of the mature HIV-1 gp120 protein (11).

  • ↵3-b CD4BD: CD4 binding domain of the gp120 molecule as in Ref. 39.