Current | ||||
---|---|---|---|---|
P2X2(a) | P2X2(b) | |||
30 μM ATP | 300 μM ATP | 30 μM ATP | 300 μM ATP | |
% | ||||
Vehicle | 95.6 ± 3.8 (n = 3)1-a | 98.3 ± 10.3 (n = 3) | 105.6 ± 11 (n = 3) | 97.0 ± 3.5 (n = 3) |
Suramin (30 μM) | 2.2 ± 0.9 (n = 5) | 19.3 ± 1.0 (n = 5) | 3.0 ± 0.5 (n = 5) | 39.3 ± 1.71-b (n = 5) |
PPADS (3 μM) | 3.8 ± 0.9 (n = 6) | 7.9 ± 1.0 (n = 10) | 6.4 ± 1.4 (n = 6) | 13.5 ± 2.11-b (n = 7) |
Data are expressed as the percentage of the ATP-induced current that remained after continuous application of the antagonist or the vehicle (which was the buffer used externally).