EC50 values for l-glutamate-, quisqualate-, and 1S,3R-ACPD-stimulated [3H]InsP1 and Ins(1,4,5)P3 mass accumulations in BHK-mGluR1α cells
| Agonist | −log EC50 | |
|---|---|---|
| [3H]InsP1 | Ins(1,4,5)P3 | |
| m | ||
| l-Glutamate | 4.67 ± 0.08 | 4.80 ± 0.09 |
| Quisqualate | 5.70 ± 0.05 | 6.18 ± 0.07 |
| 1S,3R-ACPD | 3.67 ± 0.07 | N.D. |
Concentrations of l-glutamate, quisqualate, and 1S,3R-ACPD that stimulated half-maximal increases in [3H]InsP1 accumulation (assessed at 30 min in the presence of 10 mm LiCl) or Ins(1,4,5)P3mass accumulation (assessed at 30 sec) are presented as −log EC50 ± standard error values from analyses of at least three concentration-response curves, each performed in duplicate.
N.D., An EC50 for this response could not be calculated.