Table 1

EC50 values for l-glutamate-, quisqualate-, and 1S,3R-ACPD-stimulated [3H]InsP1 and Ins(1,4,5)P3 mass accumulations in BHK-mGluR1α cells

Agonist−log EC50
l-Glutamate4.67  ± 0.084.80  ± 0.09
Quisqualate5.70  ± 0.056.18  ± 0.07
1S,3R-ACPD3.67  ± 0.07N.D.

Concentrations of l-glutamate, quisqualate, and 1S,3R-ACPD that stimulated half-maximal increases in [3H]InsP1 accumulation (assessed at 30 min in the presence of 10 mm LiCl) or Ins(1,4,5)P3mass accumulation (assessed at 30 sec) are presented as −log EC50 ± standard error values from analyses of at least three concentration-response curves, each performed in duplicate.

    • N.D., An EC50 for this response could not be calculated.