Inhibition constants of KCOs and IK-ATP antagonists for [3H]P1075 binding sites on rabbit skeletal muscle membranes.
| Compound | Ki | nH |
|---|---|---|
| μm | ||
| KCO | ||
| P1075 | 0.022 ± 0.002 | 0.89 ± 0.02 |
| Pinacidil | 0.16 ± 0.09 | 0.70 ± 0.13 |
| BMS-182264 | 0.11 ± 0.02 | 0.91 ± 0.02 |
| Levcromakalim | 1.0 ± 0.2 | 0.95 ± 0.03 |
| BRL 38226 | 54 ± 14 | 0.96 ± 0.07 |
| BMS-180448 | 0.56 ± 0.05 | 0.80 ± 0.15 |
| BMS-212345 | 22 ± 2 | 1.06 ± 0.01 |
| Nicorandil | 17 ± 3 | 0.95 ± 0.05 |
| Diazoxide | 62 ± 2 | 0.81 ± 0.02 |
| Antagonist | ||
| Glyburide | 0.13 ± 0.02 | 0.77 ± 0.04 |
| 5-Hydroxy-decanoic acid | >100 | |
| Phentolamine | >100 |
Ki values and slope factors (nH ) were calculated from competition curves as described in Materials and Methods. Values are mean ± standard error of three to seven determinations.