Table 1
Cross resistance profile at 35° of JN394t2-4 transformed with wild-type and mutant
TOP2
alleles
Plasmid
Mutation in topo somerase II
MLC
Doxorubicin
Amsacrine
Etoposide
μg/ml
YCpDEDWOB10
6
6
15
YCpDEDWOB10-R1F
G748E
50
>100
>100
YCpDEDWOB10-R2F
A642S
50
>100
>100