Inhibitor | S1-b | IN1-b | IC501-a | |
---|---|---|---|---|
3′-processing | Strand-transfer | |||
nm | nm | |||
T30177 | 20 | 330 | 80 ± 13 | > 3000 |
120 | 330 | 85 ± 15 | ||
20 | 660 | 250 ± 50 | ||
T30695 | 20 | 330 | 65 ± 10 | > 3000 |
T30677 | 20 | 330 | 550 ± 90 | > 3000 |
ss 17-mer KS | 20 | 330 | 850 ± 150 | |
ds 20-mer T3/T3-rev | 20 | 330 | 60 ± 6 | |
120 | 330 | 120 ± 15 | ||
DS50001-c | 20 | 330 | 7 ± 2 | 50 ± 10 |
120 | 330 | 7 ± 2 | ||
20 | 660 | 30 ± 5 |
↵1-a Concentration that inhibits HIV-1 integrase reaction by 50%. Results presented are mean values ± standard deviation for three or four separate experiments.
↵1-b Concentration of substrate (S) or integrase (IN) in the reaction.
↵1-c The average molecular weight of DS5000 is approximately 10,000 g/mol.