Table 1

Inhibition of integrase activities by different compounds

Inhibitor	S^1-b	IN^1-b	IC₅₀^1-a
Inhibitor	S^1-b	IN^1-b	3′-processing	Strand-transfer
	nm		nm
T30177	20	330	80 ± 13	> 3000
	120	330	85 ± 15
	20	660	250 ± 50
T30695	20	330	65 ± 10	> 3000
T30677	20	330	550 ± 90	> 3000
ss 17-mer KS	20	330	850 ± 150
ds 20-mer T3/T3-rev	20	330	60 ± 6
	120	330	120 ± 15
DS5000^1-c	20	330	7 ± 2	50 ± 10
	120	330	7 ± 2
	20	660	30 ± 5

↵1-a Concentration that inhibits HIV-1 integrase reaction by 50%. Results presented are mean values ± standard deviation for three or four separate experiments.
↵1-b Concentration of substrate (S) or integrase (IN) in the reaction.
↵1-c The average molecular weight of DS5000 is approximately 10,000 g/mol.