GABA EC50, Hill coefficients, and sensitivity to zinc of GABAA receptors expressed in X. laevis oocytes
| Subunit combination | GABA EC50 | Slope | n | Inhibition by 3 μm Zinc |
|---|---|---|---|---|
| μm | % | |||
| α1β1 | 5.4 (4.4; 6.7) | 1.32 ± 0.06 | 7 | −53.4 ± 3.8 |
| α1β1γ2 | 16.2 (12.3; 21.4) | 1.36 ± 0.18 | 7 | −4.5 ± 2.6 |
| α1β1γ1 | 15.0 (11.9; 19.1) | 1.33 ± 0.12 | 4 | −14.7 ± 3.1 |
| α1β1γ1ΔI79F | 25.0 (20.3; 30.6) | 1.8 ± 0.20 | 4 | −10.0 ± 2.4 |
| α1β1γ1ΔL132M | 51.3 (46.0; 57.2) | 1.43 ± 0.07 | 4 | −12.2 ± 3.7 |
| α1β1γ2ΔF77I | 23.7 (15.4; 36.5) | 1.5 ± 0.06 | 4 | −0.5 ± 1.6 |
EC50 values are geometric mean (− standard error, + standard error) and the slope arithmetic mean ± standard error. Inhibition by 3 μm zinc represents the percent inhibition of a GABA EC50 response for each receptor combination.