COS-7 cells (clone 134): displacement of radiolabels
| Ligand | Mean pKi | ||
|---|---|---|---|
| [125I]AC512 | [125I]hCAL | [125I]Amylin | |
| Antagonist | |||
| AC512 | 10.32 ± 0.16 | 10.36 ± 0.14 | 9.8 ± 0.24 |
| (n = 3) | (n = 3) | (n = 3) | |
| AC66 | 8.95 ± 0.165 | 9.53 ± 0.14 | N.D. |
| (n = 3) | (n = 3) | ||
| AC413 | 8.9 ± 0.1 | 7.66 ± 0.14 | 9.3 ± 0.14 |
| (n = 3) | (n = 3) | (n = 3) | |
| hCGRP8–37 | 6.5 ± 0.27 | 6.34 ± 0.30 | 6.0 ± 0.2 |
| (n = 3) | (n = 3) | (n = 3) | |
| Agonist | |||
| hCAL | 8.53 ± 0.08 | 9.0 ± 0.16 | N.D. |
| (n = 3) | (n = 3) | ||
| Rat CAL | 8.23 ± 0.12 | 8.3 ± 0.18 | N.D. |
| (n = 3) | (n = 3) | ||
| Eel CAL | 11.06 ± 0.16 | 11.36 ± 0.15 | N.D. |
| (n = 3) | (n = 3) | ||
| Porcine | 9.36 ± 0.09 | 9.53 ± 0.11 | N.D. |
| CAL | (n = 3) | (n = 3) | |
| rCGRP | 6.33 ± 0.13 | 6.6 ± 0.14 | 9.0 ± 0.12 |
| (n = 3) | (n = 3) | ||
| rAmylin | 7.1 ± 0.18 | 6.64 ± 0.21 | 9.1 ± 0.16 |
| (n = 3) | (n = 3) | (n = 3) | |