HEK 293 cells: displacement of radiolabels
| Ligand | Mean pKi | ||
|---|---|---|---|
| [125I]AC512 | [125I]hCAL | [125I]Amylin | |
| Antagonist | |||
| AC512 | 9.59 ± 0.19 | 9.37 ± 0.04 | 9.26 ± 0.17 |
| AC66 | 9.49 ± 0.17 | 9.42 ± 0.26 | 9.11 ± 0.26 |
| hCGRP8–37 | 7.36 ± 0.62 | 6.92 ± 0.14 | 7.1 ± 0.47 |
| AC187 | 9.53 ± 0.16 | 9.51 ± 0.33 | 9.39 ± 0.07 |
| AC413 | 9.05 ± 0.14 | 8.44 ± 0.12 | 9.14 ± 0.26 |
| Agonist | |||
| hCAL | 7.78 ± 0.08 | 8.93 ± 0.03 | 8.9 ± 0.56 |
| Rat CAL | 7.82 ± 0.21 | 8.65 ± 0.01 | 9.48 ± 0.14 |
| Eel CAL | 10.81 ± 0.04 | 10.91 ± 0.07 | |
| Porcine CAL | 9.53 ± 0.01 | 9.85 ± 0.08 | |
| rCGRP | 7.18 ± 0.32 | 7.8 ± 0.29 | 8.63 ± 0.30 |
| rAmylin | 7.24 ± 0.12 | 7.76 ± 0.32 | 8.9 ± 0.24 |