Table 2

Peptide antagonists and agonists

LigandAmino acid sequence
           NNLGP
           S  V
           S  L
rAmylinKCNTATCATQRLANFLVR  PPTNVGSNTYNH2
‖   ‖ ‖   ‖   ‖     ‖  ‖ ‖    ‖
sCALCSNLSTCVLGKLSQELHKLQTYPRTNTGSGTPNH2
           GVVKD
           G  N
           S  F
rCGRPSCNTATCVTHRLAGLLSR  VPTNVGSEAFNH2
hCALCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPNH2
Rat CALCGNLSTCMLGTYTQNKNKFHTFPQTSIGVGAPNH2
Eel CALCSNLSTCVLGKLSQELHKLQTYPRTDVGAGTPNH2
AC66VLGKLSQELHKLQTYPRTNTGSGTPNH2
AC512(Ac)LGXLSQELHRLQTYPRTNTGSNTY NH2
AC413ATQRLANFLVRLQTYPRTNVGANTYNH2

  • X = Bolton-Hunter-derivatized lysine.

  • Bold = amylin-like residues.