Table 3

Steady state accumulation of VLB and PBA in KB3-1 (drug-sensitive) and KB8-5 (drug-resistant) cell lines

Cell lineSteady state accumulation3-a
VLB3-bPBA3-c
pmol/106cells
KB3-13.65 ± 0.12  (n = 3)125.1 ± 8.7  (n = 13)
KB8-50.22 ± 0.03  (n = 3)127.7 ± 6.5  (n = 26)

  • ↵3-a Values are expressed as mean ± standard error (n = number of determinations).

  • ↵3-b Cells were loaded with [3H]VLB (37.5 nm, 0.5 μCi/ml) for 2 hr at room temperature.

  • ↵3-c Cells were incubated with 1 μmPBA for 1 hr at room temperature.