C_m was measured from the capacitive transients elicited by the voltage change described in Material and Methods. The control C_m was measured 5 min before the application of compounds. The compounds (100 μm glutamate, 0.25 mmhalothane, 200 mm ethanol, 0.25 mm halothane plus 100 μm glutamate, and 200 mm ethanol plus 100 μm glutamate) were applied either separately or coadministrated to oocytes as indicated. Halothane and ethanol were applied for 2 min, and glutamate was applied for 20 sec. In case of coapplication with glutamate and halothane or ethanol, halothane and ethanol were preapplied for 2 min before being coapplied with glutamate for 20 sec. After a wait of 5 or 20 min, the C_m was measured again. The control C_m did not differ among the groups: 101 ± 7 nF. Values are mean ± standard error from five or six oocytes from two batches of oocytes.