Table 3

Noncompartmental analysis of time course of various recombinant and tissue-derived ChEs in plasma of mice

Enzyme	MRT	CL	Elimination half-life	V_p^a,b	V_ss^3-a
	min	ml/hr/kg	min	ml/kg
Eq BChE	3206 ± 317	1.2	2379 ± 230	41.6 ± 1.9	57.7 ± 2.5
HuS BChE^3-c	2791	1.3	1683	51.0	58.3
tFBS AChE	1902 ± 129	1.3	1210 ± 84	30.8 ± 2.4	40.9 ± 2.8
T. californica AChE	44 ± 2	72	40 ± 7	41.2 ± 0.9	51.8 ± 1.4
mFBS AChE	304 ± 99	16.2	215 ± 14	39.5 ± 4.8	81.5 ± 8.2
rMo AChE	301 ± 40	21.6	230 ± 31	49.8 ± 4.2	107.8 ± 10.9
rHu BChE	205 ± 62	33.0	144 ± 36	54.6 ± 4.0	114 ± 20

↵3-a Normalized to body weight.
3-b Calculated by dividing the administered dose by ChE plasma concentration at t = 0, estimated by log-linearized extrapolation of the initial time course data.
↵3-c Data are average from two mice.
Values are mean ± standard deviation for three to six experiments.