Compound | Inhibition of tubulin polymerization | Inhibition of colchicine binding | Inhibition of MCF-7 growth |
---|---|---|---|
IC50 ± SD (μm) | % inhibition ± SD | IC50 ± SD (μm) | |
Curacin A | 0.72 ± 0.2 | 94 ± 2 | 0.038 ± 0.01 |
12 | 0.77 ± 0.2 | 88 ± 11 | 0.090 ± 0.01 |
13 | 2.1 ± 0.5 | 48 ± 5 | 0.36 ± 0.09 |
14 | 0.92 ± 0.2 | 83 ± 6 | 0.30 ± 0.2 |
In the colchicine binding assay, inhibitor concentration was 5.0 μm.
SD, standard deviation.