Table 4
Cyclopropyl ring modifications
| Compound | Inhibition of tubulin polymerization | Inhibition of colchicine binding | Inhibition of MCF-7 growth |
|---|---|---|---|
| IC50 ± SD (μm) | % inhibition ± SD | IC50 ± SD (μm) | |
| Curacin A | 0.72 ± 0.2 | 94 ± 2 | 0.038 ± 0.01 |
| 12 | 0.77 ± 0.2 | 88 ± 11 | 0.090 ± 0.01 |
| 13 | 2.1 ± 0.5 | 48 ± 5 | 0.36 ± 0.09 |
| 14 | 0.92 ± 0.2 | 83 ± 6 | 0.30 ± 0.2 |
In the colchicine binding assay, inhibitor concentration was 5.0 μm.
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SD, standard deviation.