Table 1

Displacement of [125I]PYY3–36 binding by various NPY receptor ligands

Receptor ligand[125I]PYY3–36 binding
30 nM100 nM
% of control
PYY20  ± 8.11-a <51-a
PYY3–36 17  ± 4.01-a 5  ± 2.81-a
NPY13–36 27  ± 8.31-a <51-a
PP88  ± 7.361  ± 8.51-a
[d-Trp32]NPY108  ± 14.876  ± 6.6
[Pro34]NPY104  ± 6.456  ± 9.61-a
BIBP 3226103  ± 13.185  ± 8.8

Peptide analogs to human sequences were used. Values represent the mean ± standard error for five animals (determined in three to six different sections) and are shown as percentage of binding obtained in the presence versus that in the absence of the respective peptide analog. Data are shown for binding in the stratum oriens of control rats. Essentially the same values were obtained in the stratum oriens 4 hr and in the dentate hilus 1 day after KA injection.

    • 1-a p < 0.01 versus control animals by analysis of variance with a Dunnett posteriori test.