Kinetic parameters of [125I]PYY3–36 binding after KA-induced seizures
| Kd | Bmax | |||
|---|---|---|---|---|
| pm | n | fmol/mg | n | |
| Stratum oriens | ||||
| Control | 10.7 ± 0.92 | 3 | 3.6 ± 0.22 | 3 |
| 6 hr after KA | 5.4 ± 0.482-a | 4 | 3.7 ± 0.13 | 4 |
| Dentate gyrus | ||||
| Control | 10.0 ± 0.92 | 3 | 0.4 ± 0.03 | 3 |
| 48 hr after KA | 10.0 ± 0.54 | 3 | 3.6 ± 0.242-a | 3 |
Kinetic analysis was calculated from autoradiograms of sections of the dorsal hippocampus incubated at five different concentrations of [125I]PYY3–36 (see Experimental Procedures). Data are expressed as mean ± standard error. The number of animals is given.
↵2-a p < 0.01 versus control animals by two-tailed Student’s t test.