K i or K m values (micromolar) for DHK, L-α-AA, PDC, KA, and SOS interaction with glutamate transport systems
| DHK | L-α-AA | PDC | KA | SOS | |
|---|---|---|---|---|---|
| Neuronal cultures (rat; this study) | 65 ± 7 (n = 5) | >1 mm | 5 ± 0.3 (n = 3) | 103 ± 9 (n = 3) | 56 ± 6 (n = 3) |
| Cortical synaptosomes (rat)1-a | 110 | 720 | 2.1 | 72 (71%; IC50) | 2.6 (26%; IC50) |
| 3,500 (21%; IC50) | 55 (74%; IC50) | ||||
| GLT1 (rat; this study) | 8 ± 1 (n = 3) | >1 mm | 312 ± 33 (n = 3) | ||
| GLTb,e (rat) | 3 | 8 | 0.7 | ||
| EAACf(rat) | 1120 | >1 mm | 14 | >1 mm | |
| EAAT1c,e(human) | >3 mm | >1 mm | 79 | >3 mm | 107 |
| EAAT2c,e(human) | 23 | >1 mm | 8 | 59 | 1157 |
| EAAT3c,e(human) | >3 mm | >1 mm | 61 | >3 mm | 150 |
| EAAT4d,e(human) | 170 | 2.6 | >5 mm |
↵1-a Garlin et al., (1995); b Pines et al., (1992); c Arriza et al., (1994); d Fairman et al., (1995); e Robinson and Dowd (1996); f Dowd et al., (1996).