Effects of SB 212047 and SB 216754 on some enzymes involved in lipid metabolism
| Compound | CoA-IT | PLA2 | 5LO | CoA-dependent acylation | Acetyltransferase | Cyclooxygenase | |
|---|---|---|---|---|---|---|---|
| Type II, 14-kDa | Type IV, 85-kDa | ||||||
| SB 212047 | 2 μm | NE at 50 μm | 10 μm; Not time-dependent | NE 50 μm | NE at 10 μm | Not tested | NE at 50 μm |
| SB 216754 | 6 μm | NE at 50 μm | NE at 50 μm | 12 μm; Not time-dependent | NE at 10 μm | 22 μm; Not time-dependent | NE at 50 μm |
CoA-IT IC50 was measured after 80 minutes of pretreatment.
NE, no significant effect