Table 1

Potentiation of wild-type and mutant receptors by anesthetics

CombinationIsoflurane (0.5 mm and 1.0 mm)Propofol (1 μm)Etomidate (10 μm)Methohexital (5 μm)Alphaxalone (1 μm)
α2β1161  ± 46 (6)124  ± 46 (7)213  ± 39 (7)234  ± 37 (6)287  ± 158 (5)
226  ± 43 (8)
α2(S270I)β15  ± 12 (6)1-a 88  ± 29 (7)236  ± 49 (5)147  ± 41 (5)211  ± 36 (5)
2  ± 6 (6)1-a
α2(S270H)β1−9  ± 2 (4)1-a 123  ± 25 (6)249  ± 56 (6)152  ± 37 (8)344  ± 100 (6)
−6  ± 2 (4)1-a
α2(A291W)β1−5  ± 5 (5)1-a 106  ± 9 (6)65  ± 27 (7)1-c 53  ± 14 (6)1-b 272  ± 178 (5)
−5  ± 3 (7)1-a
α2β1(S265I)2  ± 6 (6)1-a 68  ± 30 (8)266  ± 55 (11)238  ± 63 (10)487  ± 115 (5)
3  ± 2 (6)1-a
α2β1(M286W)9  ± 4 (6)1-a −13  ± 9 (9)1-b 122  ± 57 (11)70  ± 21 (9)1-b 383  ± 56 (6)
3  ± 11 (6)1-a

Values indicate mean ± standard error for percent potentiation of an EC20 test concentration of GABA by the anesthetic. Numbers in parentheses give number of experiments contributing to the mean value.

    • 1-a p < 0.001 compared with the control group.

    • 1-b p < 0.005 compared with the control group.

    • 1-c p < 0.01 compared with the control group.