Table 2

Intravenous anesthetic direct activation data for wild-type and mutant receptors

CombinationDirect activation by intravenous anesthetics
Propofol (50 μm)Etomidate (50 μm)Methohexital (200 μm)
% of maximal GABA current
α2β153  ± 3 (8)44  ± 6 (7)57  ± 10 (6)
α2(S270I)β136  ± 8 (11)46  ± 7 (11)75  ± 9 (5)
α2(S270H)β140  ± 8 (11)39  ± 4 (11)43  ± 7 (8)
α2(A291W)β140  ± 8 (10)30  ± 6 (8)40  ± 11 (6)
α2β1(S265I)15  ± 5 (11)2-a 18  ± 6 (11)2-b 38  ± 8 (10)
α2β1(M286W)42  ± 4 (14)26  ± 4 (19)2-b 45  ± 3 (9)
  • 2-a p < 0.001 compared with the control group.

  • 2-b p < 0.05 compared with the control group.