Sensitivity of OCBs
| Hexamethonium | Amantadine | Memantine | (+)-MK-801 | TMB-8 | |
|---|---|---|---|---|---|
| IC50 (μm) | 6.83 ± 2.18 | 3.44 ± 0.67 | 6.60 ± 0.92 | 18.71 ± 3.38 | 17.20 ± 2.88 |
| n H | 0.76 ± 0.03 | 0.73 ± 0.02 | 0.89 ± 0.04 | 0.70 ± 0.05 | 0.74 ± 0.05 |
| Cells (n) | 6 | 9 | 5 | 7 | 5 |
Mean values for IC50 and n H were determined in individual cells by fitting the dose-inhibition curve measured at −100 mV with the empirical Hill equation (see Materials and Methods).